The ATHENA Decision Support System (DSS) operationalizes guidelines for hypertension using Stanford Medical Informatics' EON architecture.

ATHENA DSS encourages blood pressure control and recommends guideline-concordant choice of drug therapy in relation to comorbid diseases. ATHENA DSS has an easily modifiable knowledge base that specifies eligibility criteria, risk stratification, blood pressure targets, relevant comorbid diseases, guideline-recommended drug c lasses for patients with comorbid disease, preferred drugs within each drug class, and clinical messages. Because evidence for best management of hypertension evolves continually, ATHENA DSS is designed to allow clinical experts to customize the knowledge base to incorporate new evidence or to reflect local interpretations of guideline ambiguities.

This system is used by a number of clinics in Northern California and Durham, North Carolina

ATHENA was developed by Stanford Medical Informatics and VA Palo Alto Health Care System
http://www.smi.stanford.edu/, http://www.palo-alto.med.va.gov/